Structural basis of second-generation HIV integrase inhibitor action and viral resistance
Abstract
Strengths and weaknesses of an HIV drug Retroviruses replicate by inserting a copy of their RNA, which has been reverse transcribed into DNA, into the host genome. This process involves the intasome, a nucleoprotein complex comprising copies of the viral integrase bound at the ends of the viral DNA. HIV integrase strand-transfer inhibitors (INSTIs) stop HIV from replicating by blocking the viral integrase and are widely used in HIV treatment....
Paper Details
Title
Structural basis of second-generation HIV integrase inhibitor action and viral resistance
Published Date
Feb 14, 2020
Journal
Volume
367
Issue
6479
Pages
806 - 810
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