Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes

Volume: 30, Issue: 4, Pages: 1223 - 1234.e8
Published: Jan 1, 2020
Abstract
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principles governing heritability remain unclear. We take a quantitative computational modeling approach to describe propagation of...
Paper Details
Title
Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes
Published Date
Jan 1, 2020
Volume
30
Issue
4
Pages
1223 - 1234.e8
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