Tracking hematopoietic stem cells and their progeny using whole-genome sequencing
Abstract
Despite decades of progress in our understanding of hematopoiesis through the study of animal models and transplantation in humans, investigating physiological human hematopoiesis directly has remained challenging. Questions on the clonal structure of the human hematopoietic stem cell (HSC) pool, such as "how many HSCs are there?" and "do all HSC clones actively produce all blood cell types in equal proportions?" remain open. These questions...
Paper Details
Title
Tracking hematopoietic stem cells and their progeny using whole-genome sequencing
Published Date
Mar 1, 2020
Journal
Volume
83
Pages
12 - 24
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