Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease.

Volume: 123, Pages: 81 - 88
Published: Jan 30, 2020
Abstract
null null Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays a neuroprotective role in LC projecting areas. We assessed functional connectivity (FC) of the brainstem in asymptomatic individuals at familial risk for AD hypothesizing that FC of the LC will be decreased in...
Paper Details
Title
Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease.
Published Date
Jan 30, 2020
Volume
123
Pages
81 - 88
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