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MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Published on Jan 30, 2020in Archives of Suicide Research2.316
路 DOI :10.1080/13811118.2019.1649772
Mu-N. Liu , Shih-Jen Tsai48
Estimated H-index: 48
+ 2 AuthorsChing-Po Lin33
Estimated H-index: 33
Abstract
Objectives: We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these medi...
  • References (27)
  • Citations (0)
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References27
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#1Davi Felix Martins J煤nior (UEFS: State University of Feira de Santana)H-Index: 2
#2Ridalva Dias Martins Felzemburgh (UFBA: Federal University of Bahia)H-Index: 7
Last. 脗ngela Miranda-Scippa (UFBA: Federal University of Bahia)H-Index: 13
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Background Attempted suicide is the main predictor of suicide constituting a major public health issue worldwide. It is estimated that for every completed suicide, 10 to 20 suicide attempts occur. Important part of the occurrences of suicide attempts in Brazil are registered in the hospital information system for coverage of more than 70 % allows to evaluate the extent of this problem in the country. The scope of this article is to analyse hospitalizations resulting from suicide attempts at publ...
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#1Jorge Luis Costa Carvalho (UNIFESP: Federal University of S茫o Paulo)H-Index: 1
Last. Fl谩vio Aimbire (UNIFESP: Federal University of S茫o Paulo)H-Index: 24
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#1Joanna 艢lusarczykH-Index: 11
#2Ewa TrojanH-Index: 10
Last. Agnieszka Basta-KaimH-Index: 25
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Abstract In spite of many years of research, the pathomechanism of depression has not yet been elucidated. Among many hypotheses, the immune theory has generated a substantial interest. Up till now, it has been thought that depression is accompanied by the activation of inflammatory response and increase in pro-inflammatory cytokine levels. However, recently this view has become controversial, mainly due to the family of small proteins called chemokines. They play a key role in the modulation of...
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Suicide in the elderly is an underestimated and complex issue that has mainly been explored in sociological, clinical and psychological perspectives. Suicide in non-elderly adults has been associated with diverse neurobiological alterations that may shed light on future predictive markers and more efficient preventative interventions. The aim of this paper was to review studies specifically investigating the neurobiology of elderly suicidal behaviour. We performed a systematic English and French...
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The aim of this study was to examine the characteristics of physicians鈥 and nurses鈥 suicide attempts (SA). A retrospective review of 493 medical records of physicians and nurses admitted to an inpatient unit for health professionals; 36 patients had a recent SA. Depression, cluster B and C personality disorders, and a history of previous SA were more prevalent in patients with a recent SA compared to those without it. Both professional groups preferred drug overdose as a suicide method. Physicia...
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#1Lena Brundin (MSU: Michigan State University)H-Index: 25
#2Sophie Erhardt (KI: Karolinska Institutet)H-Index: 37
Last. Teodor T. Postolache (UMB: University of Maryland, Baltimore)H-Index: 34
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OBJECTIVE: Over the past decade, clinical data have accumulated showing that inflammation might contribute to the pathophysiology of suicide. To evaluate the associations and to identify the support for pathways linking inflammatory processes with suicidal behaviour, a comprehensive review of the literature was undertaken. METHOD: The search terms 'cytokine', 'risk factors', 'kynurenine', 'asthma', 'allergy', 'autoimmunity', 'traumatic brain injury', 'infection' along with the terms 'inflammatio...
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#1Lindsay Hayes (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 10
#2Emily G. Severance (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 22
Last. Akira Sawa (Johns Hopkins University)H-Index: 66
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Schizophrenia (SZ) is a devastating mental condition with onset in young adulthood. The identification of molecular biomarkers that reflect illness pathology is crucial. Recent evidence suggested immune and inflammatory cascades in conjunction with infection may play a role in the pathology. To address this question, we investigated molecular changes in cerebrospinal fluid (CSF) from antipsychotic-naive patients with SZ and at risk mental status for psychosis (ARMS), in comparison with healthy c...
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#1Julie Cazareth (University of Nice Sophia Antipolis)H-Index: 10
#2Alice Guyon (University of Nice Sophia Antipolis)H-Index: 21
Last. Agn猫s Petit-Paitel (University of Nice Sophia Antipolis)H-Index: 7
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Background Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflammatory cytokines with central or peripheral origin after various insults. Systemic bacterial lipopolysaccharide (LPS) challenge is commonly used to study inflammation-induced depre...
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#1Karim Belarbi (UCSF: University of California, San Francisco)H-Index: 5
#2Timothy Jopson (UCSF: University of California, San Francisco)H-Index: 10
Last. Susanna Rosi (UCSF: University of California, San Francisco)H-Index: 31
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Cranial irradiation can lead to long-lasting cognitive impairments in patients receiving radiotherapy for the treatment of malignant brain tumors. Recent studies have suggested inflammation as a major contributor to these deficits; we determined if the chemokine (C鈥揅 motif) receptor 2 (CCR2) was a mediator of cognitive impairments induced by irradiation. Two-month-old male Ccr2 knockout (鈭/鈭) and wild-type mice received 10 Gy cranial irradiation or sham-treatment. One month after irradiation, br...
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#1Sara Bromander (KI: Karolinska Institutet)H-Index: 4
#2Rolf Anckars盲ter (University of Gothenburg)H-Index: 8
Last. Caroline Wass (University of Gothenburg)H-Index: 14
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Background Surgery launches an inflammatory reaction in the body, as seen through increased peripheral levels of cytokines and cortisol. However, less is known about perioperative inflammatory changes in the central nervous system (CNS). Our aim was to compare inflammatory markers in serum and cerebrospinal fluid (CSF) before and after surgery and evaluate their association with measures of blood鈥揵rain barrier (BBB) integrity.
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