The Anti-Neuron-Specific Enolase Antibody Induced Neuronal Cell Death in a Novel Fashion
Abstract
Suppression of ubiquitin proteasome pathway (UPP) and stimulation of caspase-3 are involved in neurodegeneration. Can UPP activators and caspase-3 inhibitors ameliorate neurodegeneration? Here, we found a novel neuronal cell death accompanied with UPP activation and caspase-3 inhibition. Recently, plasmalemmal neuron-specific enolase (NSE) has been identified as one of membrane targets of 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2). 15d-PGJ2...
Paper Details
Title
The Anti-Neuron-Specific Enolase Antibody Induced Neuronal Cell Death in a Novel Fashion
Published Date
Jan 31, 2020
Journal
Volume
57
Issue
5
Pages
2265 - 2278
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