Interleukin-23 engineering improves CAR T cell function in solid tumors
Abstract
Cytokines that stimulate T cell proliferation, such as interleukin (IL)-15, have been explored as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells. However, constitutive cytokine signaling in T cells and activation of bystander cells may cause toxicity. IL-23 is a two-subunit cytokine known to promote proliferation of memory T cells and T helper type 17 cells. We found that, upon T cell antigen receptor (TCR)...
Paper Details
Title
Interleukin-23 engineering improves CAR T cell function in solid tumors
Published Date
Feb 3, 2020
Journal
Volume
38
Issue
4
Pages
448 - 459
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