Glycemic variability modifies the relationship between time in range and hemoglobin A1c estimated from continuous glucose monitoring: A preliminary study

Although there is a linear relationship between time in range (TIR) and hemoglobin A1c (HbA1c), a great variability of calculated TIR values for a given HbA1c, and vice versa, has been reported. Whether glycemic variability accounts for part of this variability remains to be investigated.The data of continuous glucose monitoring (CGM) from 2559 patients with type 2 diabetes was analyzed. Glycemic variability was assessed by glucose coefficient...