Natural protoberberine alkaloids, identified as potent selective LSD1 inhibitors, induce AML cell differentiation
Abstract
Natural protoberberine alkaloids were first identified and characterized as potent, selective and cellular active lysine specific demethylase 1 (LSD1) inhibitors. Due to our study, isoquinoline-based tetracyclic scaffold was identified as the key structural element for their anti-LSD1 activity, subtle changes of substituents attached to the core structure led to dramatic changes of the activity. Among these protoberberine alkaloids, epiberberine...
Paper Details
Title
Natural protoberberine alkaloids, identified as potent selective LSD1 inhibitors, induce AML cell differentiation
Published Date
Apr 1, 2020
Journal
Volume
97
Pages
103648 - 103648
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