Pharmacological enrichment of polygenic risk for precision medicine in complex disorders
Abstract
Individuals with complex disorders typically have a heritable burden of common variation that can be expressed as a polygenic risk score (PRS). While PRS has some predictive utility, it lacks the molecular specificity to be directly informative for clinical interventions. We therefore sought to develop a framework to quantify an individual’s common variant enrichment in clinically actionable systems responsive to existing drugs. This was...
Paper Details
Title
Pharmacological enrichment of polygenic risk for precision medicine in complex disorders
Published Date
Jan 21, 2020
Journal
Volume
10
Issue
1
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