Hair abnormality in Netherton syndrome observed under polarized light microscopy

Background Trichorrhexis invaginata, the main diagnostic feature of Netherton syndrome, is often difficult to detect, especially in adult patients. Objective We sought to describe a characteristic feature of hairs in Netherton syndrome using a polarized light microscope and the underlying histopathologic changes. Methods Hairs obtained from 8 patients with Netherton syndrome were observed under polarized light, and we evaluated the correlation...