A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells
Abstract
Epithelial to mesenchymal transition (EMT) is a dynamic process that drives cancer cell plasticity and is thought to play a major role in metastasis. Here we show, using MDA-MB-231 cells as a model, that the plasticity of at least some metastatic breast cancer cells is dependent on the transcriptional co-regulator CBFβ. We demonstrate that CBFβ is essential to maintain the mesenchymal phenotype of triple-negative breast cancer cells and that...
Paper Details
Title
A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells
Published Date
Jan 31, 2020
Journal
Volume
39
Issue
12
Pages
2624 - 2637
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