Rapid Postnatal Upregulation of Intestinal Farnesoid X Receptor-Fibroblast Growth Factor 19 Signaling in Premature Pigs

Objectives: Bile acid (BA) homeostasis is regulated by intestinal cellular signaling involving the farnesoid X receptor (FXR) and fibroblast growth factor 19 (FGF19) secretion. Using preterm and term pigs as a model, we examined postnatal changes in expression of the FXR‐FGF19 axis that is poorly characterized in human infants. Methods: Pigs delivered by caesarean section at 10‐day preterm and near full term (115‐day gestation) were fitted with...