Dual-targeting liposome modified by glutamic hexapeptide and folic acid for bone metastatic breast cancer
Abstract
Bone is the most common organ affected by metastatic breast cancer. Targeting delivery of drugs to bone may not only enhance the treatment efficacy, but also reduce the quantity of drug administered. In order to increase the distribution of paclitaxel (PTX) in bone, herein, a novel bone metastasis-targeted glutamic hexapeptide-folic acid (Glu6-FA) derivative was designed and synthesized as liposome ligand to deliver PTX to bone metastasis...
Paper Details
Title
Dual-targeting liposome modified by glutamic hexapeptide and folic acid for bone metastatic breast cancer
Published Date
May 1, 2020
Volume
228
Pages
104882 - 104882
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