EGFRvIII-CAR-T Cells with PD-1 Knockout Have Improved Anti-Glioma Activity
Abstract
Glioblastoma multiforme (GBM) is the most malignant form of the brain tumors. EGFR variant III (EGFRvIII) is expressed in about 30% of GBM specimens, but not expressed in normal brain tissues. Therefore, EGFRvIII protein offers an ideal CAR-T therapeutic target for EGFRvIII-positive GBM patients. PD-L1 is expressed in a variety of cancer cells, including GBM. Tumor-associated PD-L1 can bind to PD-1 on T cells and promote apoptosis of T cells,...
Paper Details
Title
EGFRvIII-CAR-T Cells with PD-1 Knockout Have Improved Anti-Glioma Activity
Published Date
Jan 27, 2020
Volume
26
Issue
4
Pages
2135 - 2141
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