The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization

The water‐borne bacterium Legionella pneumophila replicates in environmental protozoa and upon inhalation destroys alveolar macrophages, thus causing a potentially fatal pneumonia termed ‘Legionnaires’ disease’. L. pneumophila employs the Legionella quorum sensing (Lqs) system to control its life cycle, pathogen–host cell interactions, motility and natural competence. Signaling through the Lqs system occurs through the α‐hydroxyketone compound...