Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen–Deuterium Exchange

Volume: 59, Issue: 5, Pages: 671 - 681
Published: Jan 20, 2020
Abstract
Protease-activated receptors (PARs) are G-protein-coupled receptors that are activated by proteolysis of the N-terminus, which exposes a tethered ligand that interacts with the receptor. Numerous studies have focused on the signaling pathways mediated by PARs. However, the structural basis for initiation of these pathways is unknown. Here, we describe a strategy for the expression and purification of PAR4. This is the first PAR family member to...
Paper Details
Title
Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen–Deuterium Exchange
Published Date
Jan 20, 2020
Volume
59
Issue
5
Pages
671 - 681
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