An Efficient Exogenous Gene Insertion Site in CHO Cells with High Transcription Level to Enhance AID‐Induced Mutation
Abstract
Antibodies have been extensively used for the purpose of scientific research, clinical diagnosis, and therapy. Combination of in vitro somatic hypermutation and mammalian cell surface display has been an efficient technology for antibody or other proteins optimization, in which the efficiency of activation‐induced cytidine deaminase (AID) mutations in genes is one of the most important key factors. Gene transcriptional level has been found to be...
Paper Details
Title
An Efficient Exogenous Gene Insertion Site in CHO Cells with High Transcription Level to Enhance AID‐Induced Mutation
Published Date
Feb 6, 2020
Journal
Volume
15
Issue
5
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