Antidepressants normalize brain flexibility associated with multi-dimensional symptoms in major depressive patients

The fundamental pathophysiology of major depressive disorder (MDD) could be characterized by functional brain networks which tightly and dynamically connect into groups as communities, making the flexible brain possible to external multifarious demands. We aim to scrutinize what brain dynamics go awry in MDD and antidepressants effects on multi-dimensional symptoms. Thirty-five patients and thirty-five controls underwent resting-state functional...