Characterization of Viral Epitopes and the HLA Restriction That Govern Anti-Adenoviral Response to Viral Specific T-Lymphocyte Therapy in a Pediatric Cohort

IntroductionAdenoviral (AdV) infections are common after HSCT and are a major cause of complications. Antiviral medications are frequently ineffective and toxic. At CCHMC, viral specific T cells (VST) from 3rd party donors are generated by pulsing peripheral blood mononuclear cells (PBMCs) with viral peptide pools (pepmix). The choice of VST product for each patient is based on pre-clinical evidence of anti-AdV activity and the degree of HLA...