Functions of human liver CD69+CD103-CD8+ T cells depend on HIF-2α activity in healthy and pathologic livers
Abstract
•CD69+CD103-CD8+ T cells are the major population of human liver CD8+ T cells. •Human liver CD69+CD103-CD8+ T cells have a terminally differentiated and tissue-resident phenotype. •Human liver CD69+CD103-CD8+ T cells specifically upregulate HIF-2α. •Effector functions and survival of human liver CD69+CD103-CD8+ T cells depend on HIF-2α. •Activation of liver CD69+CD103-CD8+ T cells with HIF-2α upregulation is observed during acute and chronic...
Paper Details
Title
Functions of human liver CD69+CD103-CD8+ T cells depend on HIF-2α activity in healthy and pathologic livers
Published Date
Jun 1, 2020
Journal
Volume
72
Issue
6
Pages
1170 - 1181
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