The Investigation of Hippocampus-Dependent Cognitive Decline Induced by Anesthesia/Surgery in Mice Through Integrated Behavioral Z-Scoring

Volume: 13
Published: Jan 22, 2020
Abstract
Objective: Patients undergoing major surgeries may experience certain cognitive decline, which is known as postoperative delirium (POD) or postoperative cognitive dysfunction (POCD). We employed integrated behavioral Z-scoring introduced by Guilloux et al. to investigate the effects of fracture fixation under anesthesia on hippocampus-dependent memory in mice. Methods: ICR mice (12-14 months) underwent stabilized tibial fracture operation under...
Paper Details
Title
The Investigation of Hippocampus-Dependent Cognitive Decline Induced by Anesthesia/Surgery in Mice Through Integrated Behavioral Z-Scoring
Published Date
Jan 22, 2020
Volume
13
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