Influence of cytoskeleton organization on recombinant protein expression by CHO cells

Volume: 117, Issue: 4, Pages: 1117 - 1126
Published: Feb 23, 2020
Abstract
In this study, we assessed the importance of cytoskeleton organization in the mammalian cells used to produce therapeutic proteins. Two cytoskeletal genes, Actin alpha cardiac muscle 1 (ACTC1) and a guanosine triphosphate GTPase-activating protein (TAGAP), were found to be upregulated in highly productive therapeutic protein-expressing Chinese hamster ovary (CHO) cells selected by the deprivation of vitamin B5. We report here that the...
Paper Details
Title
Influence of cytoskeleton organization on recombinant protein expression by CHO cells
Published Date
Feb 23, 2020
Volume
117
Issue
4
Pages
1117 - 1126
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