Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors
Abstract
The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are poorly defined. Here, we identified heart-resident PDGFRa+ SCA-1+ cells as cardiac fibro/adipogenic progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases...
Paper Details
Title
Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors
Published Date
Feb 1, 2020
Journal
Volume
26
Issue
2
Pages
205 - 220.e8
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