Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer
Abstract
Background Breast cancer is a one of the malignant carcinomas partially caused by genetic risk factors. Germline BRCA1 gene mutations are reportedly associated with breast cancers. Identification of BRCA1 mutations greatly improves the preventive strategies and management of breast cancer. The aim of our study was to investigate the frequency of the deleterious BRCA1 : p.Ile1845fs variant in breast carcinomas, as well as the correlation between...
Paper Details
Title
Profiling of the germline mutation BRCA1: p.Ile1845fs in a large cohort of Han Chinese breast cancer
Published Date
Dec 31, 2019
Journal
Volume
157
Issue
1
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