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The Buffalo OsteoPerio Studies: Summary of Our Findings and the Unique Contributions of Robert J. Genco, DDS, PhD

Published on Mar 1, 2020in Current Oral Health Reports
· DOI :10.1007/S40496-020-00257-3
Jean Wactawski-Wende67
Estimated H-index: 67
(UB: University at Buffalo),
Michael J. LaMonte39
Estimated H-index: 39
(UB: University at Buffalo)
+ 1 AuthorsHailey R. Banack11
Estimated H-index: 11
(UB: University at Buffalo)
Abstract
Purpose of Review Robert (“Bob”) Genco was a member of the research team that established the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study. Here we detail the scientific discoveries emanating from this enduring collaboration.
  • References (42)
  • Citations (0)
References42
Newest
#1Michael J. LaMonte (UB: University at Buffalo)H-Index: 39
#2Robert J. Genco (UB: University at Buffalo)H-Index: 105
Last. Jean Wactawski-Wende (UB: University at Buffalo)H-Index: 67
view all 13 authors...
Background The extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood.
1 CitationsSource
#1Robert J. Genco (UB: University at Buffalo)H-Index: 105
#2Michael J. LaMonte (UB: University at Buffalo)H-Index: 39
Last. Jean Wactawski-Wende (UB: University at Buffalo)H-Index: 67
view all 13 authors...
Understanding of the oral microbiome in relation to periodontal disease in older adults is limited. The composition and diversity of the subgingival microflora and their oligotypes in health and le...
3 CitationsSource
#1Joshua H. Gordon (UB: University at Buffalo)H-Index: 5
#2Michael J. LaMonte (UB: University at Buffalo)H-Index: 39
Last. Jean Wactawski-Wende (UB: University at Buffalo)H-Index: 67
view all 13 authors...
Introduction A possible role of the oral microbiome, specifically oral nitrate reducing flora, in blood pressure (BP) homeostasis, if proven etiologic in nature, could lead to novel mechanism-based therapy to improve hypertension prevention and control.
1 CitationsSource
#1Wei Zheng (SUNY: State University of New York System)H-Index: 40
#2Le Yang (SUNY: State University of New York System)H-Index: 4
Last. Yijun Sun (SUNY: State University of New York System)H-Index: 29
view all 6 authors...
MOTIVATION: Sequence analysis is arguably a foundation of modern biology. Classic approaches to sequence analysis are based on sequence alignment, which is limited when dealing with large-scale sequence data. A dozen of alignment-free approaches have been developed to provide computationally efficient alternatives to alignment-based approaches. However, existing methods define sequence similarity based on various heuristics and can only provide rough approximations to alignment distances. RESULT...
4 CitationsSource
#1Wei Zheng (SUNY: State University of New York System)H-Index: 40
#2Qi Mao (SUNY: State University of New York System)H-Index: 1
Last. Yijun Sun (SUNY: State University of New York System)H-Index: 29
view all 7 authors...
Motivation: The rapid development of sequencing technology has led to an explosive accumulation of genomic data. Clustering is often the first step to be performed in sequence analysis. However, existing methods scale poorly with respect to the unprecedented growth of input data size. As high-performance computing systems are becoming widely accessible, it is highly desired that a clustering method can easily scale to handle large-scale sequence datasets by leveraging the power of parallel compu...
1 CitationsSource
#1Joshua H. Gordon (UB: University at Buffalo)H-Index: 5
#2Michael J. LaMonte (UB: University at Buffalo)H-Index: 39
Last. Jean Wactawski-Wende (UB: University at Buffalo)H-Index: 67
view all 9 authors...
BACKGROUND: Multiple cross-sectional epidemiologic studies have suggested an association between periodontal disease and tooth loss and hypertension, but the temporality of these associations remains unclear. The objective of our study was to evaluate the association of baseline self-reported periodontal disease and edentulism with incident hypertension. METHODS: Study participants were 36,692 postmenopausal women in the Women's Health Initiative-Observational Study who were followed annually fr...
Source
#1Hailey R. Banack (SUNY: State University of New York System)H-Index: 11
#2Robert J. Genco (SUNY: State University of New York System)H-Index: 105
Last. Jean Wactawski-Wende (SUNY: State University of New York System)H-Index: 67
view all 12 authors...
Purpose The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study is a prospective cohort study focused on the relationship between the microbiome and oral and systemic health outcomes in postmenopausal women. The cohort was established to examine how the oral microbiome is affected by (and how it affects) periodontal disease presence, severity and progression and to characterise the relationship between the microbiome, lifestyle habits and systemic disease outcomes. Participants Parti...
3 CitationsSource
#1Michael J. LaMonteH-Index: 39
#2Robert J. GencoH-Index: 105
Last. Jean Wactawski-WendeH-Index: 67
view all 12 authors...
Aging invokes physiological changes, such as immunosenescence and inflammation, that could increase host susceptibility to oral microbiome shifts that enable periodontitis progression in later life. At present, there is a dearth of studies specifically evaluating the oral microbiome and periodontitis in older adults. We used high-throughput untargeted sequencing methods and functional metagenomic analyses to assess and compare the subgingival biofilm of postmenopausal women (mean age 71 years) a...
1 CitationsSource
#1Joshua H. Gordon (SUNY: State University of New York System)H-Index: 1
#2Michael J. LaMonte (SUNY: State University of New York System)H-Index: 39
Last. Jean Wactawski-Wende (SUNY: State University of New York System)H-Index: 67
view all 7 authors...
BACKGROUND: Hypertension and periodontal disease are common conditions among postmenopausal women. Periodontal disease has been found associated with hypertension in previous studies, but data in postmenopausal women is limited. METHODS: We assessed the cross-sectional associations of clinically measured periodontal disease with prevalent hypertension and measured systolic blood pressure (SBP) among 1341 postmenopausal women enrolled in the Buffalo Osteoporosis and Periodontal Disease (OsteoPeri...
5 CitationsSource
#1Ngozi N Nwizu (University of Texas Health Science Center at Houston)H-Index: 4
#2James R. Marshall (Roswell Park Cancer Institute)H-Index: 82
Last. Jean Wactawski-Wende (UB: University at Buffalo)H-Index: 67
view all 9 authors...
Background: Periodontal pathogens have been isolated from precancerous and cancerous lesions and also shown to promote a procarcinogenic microenvironment. Few studies have examined periodontal disease as a risk factor for total cancer, and none have focused on older women. We examined whether periodontal disease is associated with incident cancer among postmenopausal women in the Women9s Health Initiative Observational Study. Methods: Our prospective cohort study comprised 65,869 women, ages 54 ...
14 CitationsSource
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