HIFI: estimating DNA-DNA interaction frequency from Hi-C data at restriction-fragment resolution
Abstract
Hi-C is a popular technique to map three-dimensional chromosome conformation. In principle, Hi-C's resolution is only limited by the size of restriction fragments. However, insufficient sequencing depth forces researchers to artificially reduce the resolution of Hi-C matrices at a loss of biological interpretability. We present the Hi-C Interaction Frequency Inference (HIFI) algorithms that accurately estimate restriction-fragment resolution...
Paper Details
Title
HIFI: estimating DNA-DNA interaction frequency from Hi-C data at restriction-fragment resolution
Published Date
Jan 14, 2020
Journal
Volume
21
Issue
1
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