Determination of the Dissociation Constants of Metformin from a Second Derivative UV Spectrum
Volume: 11, Issue: 1, Pages: 790 - 796
Published: Jan 25, 2020
Abstract
An environmentally begnin second derivative spectrometric approach was developed for the estimation of the dissociation constants pKa(s) of metformin, a common anti-diabetic drug. The ultraviolet spectra of the aqueous solution of metformin were measured at different acidities, then the second derivative of each spectrum was graphed. The overlaid second derivative graphs exhibited two isobestic points at 225.5 nm and 244 nm pointing out to the...
Paper Details
Title
Determination of the Dissociation Constants of Metformin from a Second Derivative UV Spectrum
Published Date
Jan 25, 2020
Volume
11
Issue
1
Pages
790 - 796
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