Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma
Abstract
Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 locus and reinforces repression of selected target genes in a cellular context-dependent fashion. EfnA5 mediates Bmi1-dependent proliferation and...
Paper Details
Title
Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma
Published Date
Jan 27, 2020
Journal
Volume
39
Issue
12
Pages
2523 - 2538
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History