Comparative risk of Clostridium difficile infection between proton pump inhibitors and histamine‐2 receptor antagonists: A 15‐year hospital cohort study using a common data model

Backgrounds and Aim There are potential concerns regarding infectious complications including Clostridium difficile infections (CDIs) among patients taking gastric acid suppressants. Furthermore, it is speculated that the stronger acid suppression by proton pump inhibitors (PPIs) potentially enhance infectious complications. This study aimed to compare the risk of CDI between PPIs and histamine‐2 receptor antagonists (H2RAs). Methods Using the...