British Society for Rheumatology guideline on diagnosis and treatment of giant cell arteritis: executive summary.

Published on Mar 1, 2020in Rheumatology5.149
Sarah L. Mackie19
Estimated H-index: 19
(University of Leeds),
Christian Dejaco27
Estimated H-index: 27
(University of Graz)
+ 33 AuthorsAlexandre Wagner Silva de Souza13
Estimated H-index: 13
(UNIFESP: Federal University of São Paulo)
  • References (19)
  • Citations (0)
#2Karin Niedermann (Zürcher Fachhochschule)H-Index: 8
Last. Theodora P M Vliet Vlieland (American Physical Therapy Association)H-Index: 2
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Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. We evaluated if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on PA in clinical practice. The EULAR standardised operating procedures for the develo...
28 CitationsSource
#1Christian DejacoH-Index: 27
#2Sofia Ramiro (LUMC: Leiden University Medical Center)H-Index: 27
Last. Wolfgang A. SchmidtH-Index: 32
view all 20 authors...
To develop evidence-based recommendations for the use of imaging modalities in primary large vessel vasculitis (LVV) including giant cell arteritis (GCA) and Takayasu arteritis (TAK). European League Against Rheumatism (EULAR) standardised operating procedures were followed. A systematic literature review was conducted to retrieve data on the role of imaging modalities including ultrasound, MRI, CT and [18F]-fluorodeoxyglucose positron emission tomography (PET) in LVV. Based on evidence and expe...
114 CitationsSource
#1Lenore M. Buckley (Yale University)H-Index: 4
#2Gordon H. Guyatt (McMaster University)H-Index: 201
Last. Timothy E. McAlindon (Tufts University)H-Index: 57
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Objective To develop recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP). Methods We conducted a systematic review to synthesize the evidence for the benefits and harms of GIOP prevention and treatment options. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of evidence. We used a group consensus process to determine the final recommendations and grade their strength. The guideline addresses ini...
106 CitationsSource
#1Lenore M. Buckley (Yale University)H-Index: 4
#2Gordon H. Guyatt (McMaster University)H-Index: 201
Last. Timothy E. McAlindon (Tufts Medical Center)H-Index: 57
view all 21 authors...
53 CitationsSource
#1John H. Stone (Harvard University)H-Index: 70
#2Katie Tuckwell (Hoffmann-La Roche)H-Index: 8
Last. Neil Collinson (Hoffmann-La Roche)H-Index: 9
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BackgroundGiant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arteritis. MethodsIn this 1-year trial, we randomly assigned 251 patients, in a 2:1:1:1 ratio, to receive subcutaneous tocilizumab (at a dose of 162 mg) weekly or every other week...
207 CitationsSource
#1Carol A. Langford (Cleveland Clinic)H-Index: 40
#2David Cuthbertson (USF: University of South Florida)H-Index: 35
Last. Jennifer HarrisH-Index: 1
view all 45 authors...
Objective To compare the efficacy of abatacept to that of placebo for the treatment of giant cell arteritis (GCA). Methods In this multicenter trial, patients with newly diagnosed or relapsing GCA were treated with abatacept 10 mg/kg intravenously on days 1, 15, and 29 and week 8, together with prednisone administered daily. At week 12, patients in remission underwent a double-blinded randomization to continue to receive abatacept monthly or switch to placebo. Patients in both study arms receive...
109 CitationsSource
#1Peter M. Villiger (University of Bern)H-Index: 44
#2Sabine Adler (University of Bern)H-Index: 10
Last. Stephan Reichenbach Oberarzt (University of Bern)H-Index: 36
view all 9 authors...
Summary Background Giant cell arteritis is an immune-mediated disease of medium and large-sized arteries that affects mostly people older than 50 years of age. Treatment with glucocorticoids is the gold-standard and prevents severe vascular complications but is associated with substantial morbidity and mortality. Tocilizumab, a humanised monoclonal antibody against the interleukin-6 receptor, has been associated with rapid induction and maintenance of remission in patients with giant cell arteri...
188 CitationsSource
#1Christian Dejaco (Medical University of Graz)H-Index: 27
#2Yogesh P. Singh (Southend University Hospital NHS Foundation Trust)H-Index: 3
Last. Bhaskar Dasgupta (Southend University Hospital NHS Foundation Trust)H-Index: 35
view all 46 authors...
Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) recommendations for the management of PMR. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology as a framework for the project. Accordingly, the direction and strength of the recomme...
65 CitationsSource
#1Ana García-Martínez (University of Barcelona)H-Index: 23
#2Pedro Arguis (University of Barcelona)H-Index: 13
Last. Maria C. Cid (University of Barcelona)H-Index: 52
view all 9 authors...
Background Aortic structural damage (ASD) may complicate the course of patients with giant cell arteritis (GCA). However the frequency and outcome of ASD has not been assessed in long term prospective studies. Methods In a previous screening of 54 biopsy proven GCA patients, significant ASD was detected in 12 (22.2%) after a median follow-up of 5.4 years. These patients were periodically evaluated (every 4 years) over a median of 10.3 years (range 4–16.6 years) in order to investigate the develo...
56 CitationsSource
#1Sarah L. MackieH-Index: 19
Last. Colin T. Pease (Leeds Teaching Hospitals NHS Trust)H-Index: 32
view all 4 authors...
Objectives To review the literature in order to estimate how many previously unknown thoracic aortic aneurysms (TAAs) and thoracic aortic dilatations (TADs) might be detected by systematic, cross-sectional aortic imaging of patients with giant cell arteritis (GCA). Methods A systematic literature review was performed using Ovid Medline, Embase and the Cochrane Library. Studies potentially relevant to TAA/TAD were evaluated by two authors independently for relevance, bias and heterogeneity. Meta-...
38 CitationsSource
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