HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair
Abstract
The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopic production of HSF2BP, a BRCA2-interacting protein required for meiotic HR during mouse spermatogenesis, in non-germline human cells acutely sensitize them to ICL-inducing agents (mitomycin C and cisplatin) and PARP inhibitors, resulting in a phenotype characteristic...
Paper Details
Title
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair
Published Date
Jan 21, 2020
Journal
Volume
48
Issue
5
Pages
2442 - 2456
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