Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Abstract
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that are aneuploid or exhibit a CIN phenotype. We find that aneuploid cells are much more sensitive to the energy metabolism regulating drug ZLN005 than...
Paper Details
Title
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Published Date
Jan 24, 2020
Journal
Volume
3
Issue
2
Pages
e201900499 - e201900499
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