Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack
Abstract
Cellular processes, such as DNA replication, recombination and transcription, require DNA strands separation and single-stranded DNA is formation. The single-stranded DNA is promptly wrapped by human single-stranded DNA binding proteins, replication protein A (RPA) complex. RPA binding not only prevent nuclease degradation and annealing, but it also coordinates cell-cycle checkpoint activation and DNA repair. However, RPA binding offers little...
Paper Details
Title
Single-stranded DNA damage: Protecting the single-stranded DNA from chemical attack
Published Date
Mar 1, 2020
Journal
Volume
87
Pages
102804 - 102804
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