DENDRO: genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing
Abstract
Although scRNA-seq is now ubiquitously adopted in studies of intratumor heterogeneity, detection of somatic mutations and inference of clonal membership from scRNA-seq is currently unreliable. We propose DENDRO, an analysis method for scRNA-seq data that clusters single cells into genetically distinct subclones and reconstructs the phylogenetic tree relating the subclones. DENDRO utilizes transcribed point mutations and accounts for technical...
Paper Details
Title
DENDRO: genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing
Published Date
Jan 14, 2020
Journal
Volume
21
Issue
1
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