The Role of Muscle Protein and Energy Metabolism in Statin-Associated Muscle Symptoms
Abstract
Animal models of overt statin myopathy reveal clear negative effects on muscle protein and carbohydrate metabolism, which appear to be linked to changes in Akt/FOXO signalling. Forcibly increasing muscle carbohydrate flux under these conditions by pharmacological means blocks statin myopathy. Human volunteer research has delivered less definitive mechanistic insight of the aetiology of statin-related metabolic dysregulation, with little evidence...
Paper Details
Title
The Role of Muscle Protein and Energy Metabolism in Statin-Associated Muscle Symptoms
Published Date
Jan 1, 2020
Journal
Pages
113 - 120
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Notes
History