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An fMRI-based neural marker for migraine without aura

Published on Feb 18, 2020in Neurology8.689
路 DOI :10.1212/WNL.0000000000008962
Yiheng Tu7
Estimated H-index: 7
,
Fang Zeng14
Estimated H-index: 14
+ 13 AuthorsCourtney Lang6
Estimated H-index: 6
Abstract
Objective To identify and validate an fMRI-based neural marker for migraine without aura (MwoA) and to examine its association with treatment response. Methods We conducted cross-sectional studies with resting-state fMRI data from 230 participants and machine learning analyses. In studies 1 through 3, we identified, cross-validated, independently validated, and cross-sectionally validated an fMRI-based neural marker for MwoA. In study 4, we assessed the relationship between the neural marker and treatment responses in migraineurs who received a 4-week real or sham acupuncture treatment, or were waitlisted, in a registered clinical trial. Results In study 1 (n = 116), we identified a neural marker with abnormal functional connectivity within the visual, default mode, sensorimotor, and frontal-parietal networks that could discriminate migraineurs from healthy controls (HCs) with 93% sensitivity and 89% specificity. In study 2 (n = 38), we investigated the generalizability of the marker by applying it to an independent cohort of migraineurs and HCs and achieved 84% sensitivity and specificity. In study 3 (n = 76), we verified the specificity of the marker with new datasets of migraineurs and patients with other chronic pain disorders (chronic low back pain and fibromyalgia) and demonstrated 78% sensitivity and 76% specificity for discriminating migraineurs from nonmigraineurs. In study 4 (n = 116), we found that the changes in the marker responses showed significant correlation with the changes in headache frequency in response to real acupuncture. Conclusion We identified an fMRI-based neural marker that captures distinct characteristics of MwoA and can link disease pattern changes to brain changes.
  • References (48)
  • Citations (1)
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References48
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#1Yiheng TuH-Index: 7
#2Zening FuH-Index: 8
Last. Jian KongH-Index: 45
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Objective To investigate the dynamic functional connectivity of thalamocortical networks in interictal migraine patients and whether clinical features are associated with abnormal connectivity. Methods We investigated dynamic functional network connectivity (dFNC) of the migraine brain in 89 interictal migraine patients and 70 healthy controls. We focused on the temporal properties of thalamocortical connectivity using sliding window cross-correlation, clustering state analysis, and graph-theory...
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#1Minyoung Jung (University of Fukui)H-Index: 8
#2Yiheng Tu (Harvard University)H-Index: 7
Last. Jian Kong (Harvard University)H-Index: 45
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Background Both attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are neurodevelopmental disorders with a high prevalence. They are often comorbid and both exhibit abnormalities in sustained attention, yet common and distinct neural patterns of ASD and ADHD remain unidentified. Aims To investigate shared and distinct functional connectivity patterns in a relatively large sample of boys (7- to 15-year-olds) with ADHD, ASD and typical development matched by age, ge...
2 CitationsSource
#1Yiheng TuH-Index: 7
#2Minyoung JungH-Index: 8
Last. Jian KongH-Index: 45
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AbstractAccumulating evidence has shown that complicated brain systems are involved in the development and maintenance of chronic low back pain (cLBP), but the association between brain functional changes and clinical outcomes remains unclear. Here, we used resting-state functional magnetic resonanc
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#1Yiheng Tu (Harvard University)H-Index: 7
#2Ana Ortiz (Harvard University)H-Index: 3
Last. Jian Kong (Harvard University)H-Index: 45
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Abstract Despite the high prevalence and socioeconomic impact of chronic low back pain (cLBP), treatments for cLBP are often unsatisfactory, and effectiveness varies widely across patients. Recent neuroimaging studies have demonstrated abnormal resting-state functional connectivity (rsFC) of the default mode, salience, central executive, and sensorimotor networks in chronic pain patients, but their role as predictors of treatment responsiveness has not yet been explored. In this study, we used m...
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Purpose of reviewPrimary headaches, such as migraine and cluster headache, are one of the most common and disabling neurological diseases worldwide. Neuroimaging studies have changed the way we understand these diseases and have enriched our knowledge of the mechanisms of actions of currently availa
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Abstract Since initial reports regarding the impact of motion artifact on measures of functional connectivity, there has been a proliferation of participant-level confound regression methods to limit its impact. However, many of the most commonly used techniques have not been systematically evaluated using a broad range of outcome measures. Here, we provide a systematic evaluation of 14 participant-level confound regression methods in 393 youths. Specifically, we compare methods according to fou...
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Plaguing humans for more than two millennia, manifest on every continent studied, and with more than one billion patients having an attack in any year, migraine stands as the sixth most common cause of disability on the planet. The pathophysiology of migraine has emerged from a historical consideration of the "humors" through mid-20th century distraction of the now defunct Vascular Theory to a clear place as a neurological disorder. It could be said there are three questions: why, how, and when?...
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#1Lingdi Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 19
#2Jiao Chen (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 5
Last. Fanrong Liang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 26
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Importance The long-term prophylactic effects of acupuncture for migraine are uncertain. Objective To investigate the long-term effects of true acupuncture compared with sham acupuncture and being placed in a waiting-list control group for migraine prophylaxis. Design, Setting, and Participants This was a 24-week randomized clinical trial (4 weeks of treatment followed by 20 weeks of follow-up). Participants were randomly assigned to true acupuncture, sham acupuncture, or a waiting-list control ...
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Abstract Resting-state functional Magnetic Resonance Imaging (R-fMRI) holds the promise to reveal functional biomarkers of neuropsychiatric disorders. However, extracting such biomarkers is challenging for complex multi-faceted neuropathologies, such as autism spectrum disorders. Large multi-site datasets increase sample sizes to compensate for this complexity, at the cost of uncontrolled heterogeneity. This heterogeneity raises new challenges, akin to those face in realistic diagnostic applicat...
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One of the most exciting developments in modern neuroscience has been the expansion of imaging techniques that can provide insights into human brain structures and networks that could be involved in the pathophysiology of diseases. A series of MRI techniques have been extensively applied to the study of patients with migraine. It is now widely accepted that migraine should be viewed as a complex brain network disorder with a strong genetic basis that involves the interplay of multiple neuronal s...
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