Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion
Abstract
Maintenance of protein homeostasis, through inducible expression of molecular chaperones, is essential for cell survival under protein-damaging conditions. The expression and DNA-binding activity of heat shock factor 2 (HSF2), a member of the heat shock transcription factor family, increase upon exposure to prolonged proteotoxicity. Nevertheless, the specific roles of HSF2 and the global HSF2-dependent gene expression profile during sustained...
Paper Details
Title
Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion
Published Date
Jan 1, 2020
Journal
Volume
30
Issue
2
Pages
583 - 597.e6
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