Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet

Calorie restriction (CR) is considered one of the most robust ways to extend life span and reduce the risk of age-related diseases, including cancer, as shown in many different organisms. On the contrary, high fat diet (HFD)-induced obesity was found to shorten life expectancy which is associated with development of various diseases. Despite the proven contribution of sirtuins in mediating the effects of CR in longevity, the involvement of these...