Original paper
Structural dynamics and allostery of Rab proteins: strategies for drug discovery and design
Abstract
Rab proteins represent the largest family of the Rab superfamily guanosine triphosphatase (GTPase). Aberrant human Rab proteins are associated with multiple diseases, including cancers and neurological disorders. Rab subfamily members display subtle conformational variations that render specificity in their physiological functions and can be targeted for subfamily-specific drug design. However, drug discovery efforts have not focused much on...
Paper Details
Title
Structural dynamics and allostery of Rab proteins: strategies for drug discovery and design
Published Date
Jan 17, 2020
Journal
Volume
22
Issue
1
Pages
270 - 287
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Notes
History