Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses
Abstract
Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role of p53 in regulating the anti-tumor immune response is still poorly understood. Here, we show that loss of p53 in cancer cells modulates the tumor-immune landscape to circumvent immune destruction. Deletion of p53 promotes the recruitment and instruction of suppressive myeloid CD11b+...
Paper Details
Title
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses
Published Date
Jan 1, 2020
Journal
Volume
30
Issue
2
Pages
481 - 496.e6
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