The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research
Abstract
Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms despite ≥2 trials of adequate dose and duration of antipsychotic medication with documented adherence, is a serious clinical problem with heterogeneous presentations. TRS can vary in its onset (at the first episode of psychosis or upon relapse), in its severity, and in the response to subsequent therapeutic interventions (i.e., clozapine, electroconvulsive therapy)....
Paper Details
Title
The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research
Published Date
Jan 7, 2020
Journal
Volume
6
Issue
1
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