The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

Volume: 432, Issue: 5, Pages: 1367 - 1394
Published: Mar 1, 2020
Abstract
Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the hypoglycemic action of insulin and strongly contributes to the correction of acute hypoglycemia. The mechanisms by which glucose controls glucagon secretion are hotly debated, and it is still unclear to what extent this control results from a direct action of glucose on α-cells or is indirectly mediated by β- and/or δ-cells. Besides its hyperglycemic action,...
Paper Details
Title
The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes
Published Date
Mar 1, 2020
Volume
432
Issue
5
Pages
1367 - 1394
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