Biased modulators of NMDA receptors control channel opening and ion selectivity

Volume: 16, Issue: 2, Pages: 188 - 196
Published: Jan 20, 2020
Abstract
Allosteric modulators of ion channels typically alter the transitions rates between conformational states without changing the properties of the open pore. Here we describe a new class of positive allosteric modulators of N-methyl d-aspartate receptors (NMDARs) that mediate a calcium-permeable component of glutamatergic synaptic transmission and play essential roles in learning, memory and cognition, as well as neurological disease. EU1622-14...
Paper Details
Title
Biased modulators of NMDA receptors control channel opening and ion selectivity
Published Date
Jan 20, 2020
Volume
16
Issue
2
Pages
188 - 196
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