Match!

Longitudinal changes of resting-state functional connectivity of amygdala following fear learning and extinction

Published on Jan 9, 2020in International Journal of Psychophysiology2.407
· DOI :10.1016/j.ijpsycho.2020.01.002
Olga Martynova4
Estimated H-index: 4
(HSE: National Research University – Higher School of Economics),
Alina Tetereva1
Estimated H-index: 1
(RAS: Russian Academy of Sciences)
+ 3 AuthorsA. M. Ivanitsky8
Estimated H-index: 8
(RAS: Russian Academy of Sciences)
Abstract
Abstract Altered functional connectivity of the amygdala has been observed in a resting state immediately after fear learning, even one day after aversive exposure. The persistence of increased resting-state functional connectivity (rsFC) of the amygdala has been a critical finding in patients with stress and anxiety disorders. However, longitudinal changes in amygdala rsFC have rarely been explored in healthy participants. To address this issue, we studied the rsFC of the amygdala in two groups of healthy volunteers. The control group participated in three fMRI scanning sessions of their resting state at the first visit, one day, and one week later. The experimental group participated in three fMRI sessions on the first day: a resting state before fear conditioning, a fear extinction session, and a resting state immediately after fear extinction. Furthermore, this group experienced scanning after one day and week. The fear-conditioning paradigm consisted of visual stimuli with a distinct rate of partial reinforcement by electric shock. During the extinction, we presented the same stimuli in another sequence without aversive pairing. In the control group, rsFC maps were statistically similar between sessions for the left and right amygdala. However, in the experimental group, the increased rsFC mainly of the left amygdala was observed after extinction, one day, and one week. The between-group comparison also demonstrated an increase in the left amygdala rsFC in the experimental group. Our results indicate that functional connections of the left amygdala influenced by fear learning may persist for several hours and days in the human brain.
  • References (61)
  • Citations (1)
📖 Papers frequently viewed together
78% of Scinapse members use related papers. After signing in, all features are FREE.
References61
Newest
#1Camilla L. NordH-Index: 6
#2Alan GrayH-Index: 2
Last. Jonathan P. RoiserH-Index: 46
view all 4 authors...
One of the most exciting translational prospects for brain imaging research is the potential use of functional magnetic resonance imaging (fMRI) ‘biomarkers’ to predict an individual’s risk of developing a neuropsychiatric disorder or the likelihood of responding to a particular intervention. This proposal depends critically on reliable measurements at the level of the individual. Several previous studies have reported relatively poor reliability of amygdala activation during emotional face proc...
1 CitationsSource
#1Emily L. Belleau (Harvard University)H-Index: 6
#2Walker S. Pedersen (UW: University of Wisconsin-Madison)H-Index: 5
Last. Christine L. Larson (UWM: University of Wisconsin–Milwaukee)H-Index: 30
view all 5 authors...
1 CitationsSource
#1Miquel A. Fullana (Autonomous University of Barcelona)H-Index: 17
Last. Ben J. Harrison (University of Melbourne)H-Index: 45
view all 8 authors...
Abstract The study of fear extinction represents an important example of translational neuroscience in psychiatry and promises to improve the understanding and treatment of anxiety and fear-related disorders. We present the results of a set of meta-analyses of human fear extinction studies in healthy participants, conducted with functional magnetic resonance imaging (fMRI) and reporting whole-brain results. Meta-analyses of fear extinction learning primarily implicate consistent activation of br...
29 CitationsSource
#1Ye Ha Jung (Seoul National University Hospital)H-Index: 3
#2Jung E. Shin (Seoul National University Hospital)H-Index: 1
Last. Soo-Hee Choi (SNU: Seoul National University)H-Index: 5
view all 6 authors...
Background: The amygdala plays a key role in emotional hyperreactivity in response to social threat in patients with social anxiety disorder (SAD). We investigated resting-state functional connectivity (rs-FCN) of the left and right amygdala with various brain regions and functional lateralization in patients with SAD. Methods: A total of 36 patients with SAD and 42 matched healthy controls underwent functional magnetic resonance imaging at rest. Using the left and right amygdala as seed regions...
2 CitationsSource
#1Despina E. Ganella (University of Melbourne)H-Index: 12
#2Marjolein E.A. Barendse (University of Melbourne)H-Index: 3
Last. Sarah Whittle (University of Melbourne)H-Index: 33
view all 4 authors...
While deficits in fear extinction recall have been suggested to underlie vulnerability to anxiety disorders in adolescents, the neurobiology of these deficits remain underexplored. Here we investigate the functional connectivity of the ventromedial prefrontal cortex (vmPFC) and dorsolateral PFC (dlPFC) underlying extinction recall in healthy adolescents, and assess associations between FC and state/trait anxiety. Adolescents (17) and adults (14, for comparison) completed a fear-learning paradigm...
6 CitationsSource
#1Camilla L. Nord (UCL: University College London)H-Index: 6
#2Alan Gray (UCL: University College London)H-Index: 2
Last. Jonathan P. Roiser (UCL: University College London)H-Index: 46
view all 5 authors...
There is considerable need to develop tailored approaches to psychiatric treatment. Numerous researchers have proposed using functional magnetic resonance imaging (fMRI) biomarkers to predict therapeutic response, in particular by measuring task-evoked subgenual anterior cingulate (sgACC) and amygdala activation in mood and anxiety disorders. Translating this to the clinic relies on the assumption that blood-oxygen-level dependent (BOLD) responses in these regions are stable within individuals. ...
26 CitationsSource
#1Je Yeon Yun (Seoul National University Hospital)H-Index: 2
#2Jae Chang Kim (Yonsei University)H-Index: 1
Last. Soo-Hee Choi (SNU: Seoul National University)H-Index: 5
view all 6 authors...
Abstract Background Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD. Methods In total, for 28 SAD patients and 27 healthy controls (HC), f...
8 CitationsSource
#1Oana Georgiana Rus (LMU: Ludwig Maximilian University of Munich)H-Index: 5
#2Tim Jonas Reess (LMU: Ludwig Maximilian University of Munich)H-Index: 5
Last. Kathrin Koch (LMU: Ludwig Maximilian University of Munich)H-Index: 31
view all 6 authors...
Background The amygdala is known to be involved in anxiety processing, but its role in the psychopathology of obsessive-compulsive disorder (OCD) is still unclear.
10 CitationsSource
#1Erno J. Hermans (Radboud University Nijmegen)H-Index: 39
#2Jonathan W. Kanen (University of Cambridge)H-Index: 5
Last. Elizabeth A. Phelps (Center for Neural Science)H-Index: 73
view all 6 authors...
After encoding, memories undergo a process of consolidation that determines long-term retention. For conditioned fear, animal models postulate that consolidation involves reactivations of neuronal assemblies supporting fear learning during postlearning "offline" periods. However, no human studies to date have investigated such processes, particularly in relation to long-term expression of fear. We tested 24 participants using functional MRI on 2 consecutive days in a fear conditioning paradigm i...
33 CitationsSource
#1M. A. Fullana (Autonomous University of Barcelona)H-Index: 3
#2Ben J. Harrison (University of Melbourne)H-Index: 45
Last. Joaquim Radua ('KCL': King's College London)H-Index: 42
view all 7 authors...
Classical Pavlovian fear conditioning remains the most widely employed experimental model of fear and anxiety, and continues to inform contemporary pathophysiological accounts of clinical anxiety disorders. Despite its widespread application in human and animal studies, the neurobiological basis of fear conditioning remains only partially understood. Here we provide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional magnetic resonance imaging (fMRI), yie...
145 CitationsSource
Cited By1
Newest
#1Alina TeterevaH-Index: 1
#2Sergey I. Kartashov (Kurchatov Institute)H-Index: 3
Last. Olga Martynova (RAS: Russian Academy of Sciences)H-Index: 4
view all 4 authors...
Previous studies showed differences in brain dynamics during rest and different tasks. We aimed to find changes of variance and scale-free properties of blood oxygenation level-dependent (BOLD) signal between resting-state sessions before and after fear learning and fear memory extinction in twenty-three healthy right-handed volunteers. During a 1-hour break between MRI-scanning, subjects passed through fear extinction procedure, followed by Pavlovian fear conditioning with weak electrical stimu...
Source