Functional mitral regurgitation and left atrial myopathy in heart failure with preserved ejection fraction

Aims Mild to moderate functional mitral regurgitation (MR) is common in patients with heart failure and preserved ejection fraction (HFpEF) where it is usually considered as an innocent bystander. We hypothesized that MR in HFpEF reflects greater left atrial (LA) myopathy, leading to more adverse haemodynamics and poorer exercise reserve. Methods and results Patients with HFpEF ( n = 280) with and without MR underwent echocardiography, invasive...