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Associations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study.

Published on Jan 13, 2020in Environmental Health4.43
路 DOI :10.1186/s12940-020-0561-8
Gang Liu18
Estimated H-index: 18
(HUST: Huazhong University of Science and Technology),
Bo Zhang (Fukuoka University)+ 9 AuthorsQi Sun62
Estimated H-index: 62
(Harvard University)
Abstract
Background The associations of perfluoroalkyl substance (PFAS) exposure with blood lipids and lipoproteins are inconsistent, and existing studies did not account for metabolic heterogeneity of lipoprotein subspecies. This study aimed to examine the associations between plasma PFAS concentrations and lipoprotein and apolipoprotein subspecies.
  • References (39)
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References39
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#1Carolina Donat-Vargas (KI: Karolinska Institutet)H-Index: 3
#2Ingvar A. Bergdahl (Ume氓 University)H-Index: 33
Last. Agneta 脜kesson (KI: Karolinska Institutet)H-Index: 40
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Background: Perfluoroalkyl substances (PFAS) are persistent synthetic chemicals that may affect components of metabolic risk through the peroxisome proliferator-activated receptor but epidemiologic ...
2 CitationsSource
#1Elsie M. Sunderland (Harvard University)H-Index: 33
#2Xindi C. Hu (Harvard University)H-Index: 7
Last. Joseph G. Allen (Harvard University)H-Index: 20
view all 6 authors...
Here, we review present understanding of sources and trends in human exposure to poly- and perfluoroalkyl substances (PFASs) and epidemiologic evidence for impacts on cancer, immune function, metabolic outcomes, and neurodevelopment. More than 4000 PFASs have been manufactured by humans and hundreds have been detected in environmental samples. Direct exposures due to use in products can be quickly phased out by shifts in chemical production but exposures driven by PFAS accumulation in the ocean ...
14 CitationsSource
#1Mengmeng Huang (ZJU: Zhejiang University)H-Index: 5
#2Jingjing Jiao (ZJU: Zhejiang University)H-Index: 10
Last. Yu Zhang (ZJU: Zhejiang University)H-Index: 24
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Abstract Background Perfluoroalkyl chemicals (PFCs) as possible cardiovascular disrupters are universally detected in humans. However, evidence from epidemiological studies appears insufficient and ambiguous. Objectives We aim to examine the serum PFCs levels and their associations with the prevalence of cardiovascular diseases (CVD) and related outcomes in general US population. Methods We investigated the serum levels of 12 major PFCs, including perfluorooctanoic acid (PFOA), perfluorooctane s...
8 CitationsSource
Source
#1Allyson M. Morton (Harvard University)H-Index: 4
#2Manja Koch (Harvard University)H-Index: 12
Last. Frank M. Sacks (Harvard University)H-Index: 110
view all 9 authors...
7 CitationsSource
#1Gang Liu (Harvard University)H-Index: 18
#2Klodian Dhana (Harvard University)H-Index: 17
Last. Qi Sun (Harvard University)H-Index: 62
view all 12 authors...
Background The potential endocrine-disrupting effects of perfluoroalkyl substances (PFASs) have been demonstrated in animal studies, but whether PFASs may interfere with body weight regulation in humans is largely unknown. This study aimed to examine the associations of PFAS exposure with changes in body weight and resting metabolic rate (RMR) in a diet-induced weight-loss setting. Methods and findings In the 2-year POUNDS Lost randomized clinical trial based in Boston, Massachusetts, and Baton ...
23 CitationsSource
#1Diana Sanchez Garcia (KI: Karolinska Institutet)H-Index: 1
#2Marcus Sj枚din (KI: Karolinska Institutet)H-Index: 5
Last. Vesna Munic Kos (KI: Karolinska Institutet)H-Index: 2
view all 10 authors...
Abstract Many chemicals accumulate in organisms through a variety of different mechanisms. Cationic amphiphilic drugs (CADs) accumulate in lysosomes and bind to membranes causing phospholipidosis, whereas many lipophilic chemicals target adipose tissue. Perfluoroalkyl substances (PFASs) are widely used as surfactants, but many of them are highly bioaccumulating and persistent in the environment, making them notorious environmental toxicants. Understanding the mechanisms of their bioaccumulation ...
10 CitationsSource
#1Moritz Wyler von Ballmoos (MCW: Medical College of Wisconsin)H-Index: 15
#2Bernhard Haring (University of W眉rzburg)H-Index: 11
Last. Frank M. Sacks (Harvard University)H-Index: 110
view all 3 authors...
Background Apolipoprotein CIII (apoC-III) is an atherogenic protein found on HDL, VLDL and聽LDL. Objective The objective of this study is to review the literature on the association of blood apoC-III level with cardiovascular events and the dose-response relationship for this association. Methods and results MEDLINE, EMBASE, BIOSIS, CINAHL, Clinicaltrials.gov, grey-literature sources, contact with investigators, and reference lists of studies, without language restrictions, were reviewed. Twelve ...
43 CitationsSource
#1Kenneth R FeingoldH-Index: 24
#2Carl GrunfeldH-Index: 5
35 Citations
#1Xiao-Wen Zeng (SYSU: Sun Yat-sen University)H-Index: 8
#2Zhengmin Qian (SLU: Saint Louis University)H-Index: 24
Last. D Guang-Hui (SYSU: Sun Yat-sen University)H-Index: 26
view all 10 authors...
Abstract Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on ser...
24 CitationsSource
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