Estimating the impact of drug use on US mortality, 1999-2016

The impact of rising drug use on US mortality may extend beyond deaths coded as drug-related to include excess mortality from other causes affected by drug use. Here, we estimate the full extent of drug-associated mortality. We use annual death rates for 1999–2016 by state, sex, five-year age group, and cause of death to model the relationship between drug-coded mortality—which serves as an indicator of the population-level prevalence of drug...