Theta-burst stimulation and frontotemporal regulation of cardiovascular autonomic outputs: The role of state anxiety

Published on Jan 7, 2020in International Journal of Psychophysiology2.407
路 DOI :10.1016/j.ijpsycho.2019.12.011
Tasha Poppa3
Estimated H-index: 3
(SC: University of Southern California),
Sara De Witte3
Estimated H-index: 3
(UGent: Ghent University)
+ 2 AuthorsChris Baecken30
Estimated H-index: 30
(UGent: Ghent University)
Abstract Dysregulation of autonomic cardiovascular homeostasis is an important cardiological and neurological risk factor. Cortical regions including the prefrontal and insular cortices exert tonic control over cardiovascular autonomic functions. Transcranial Magnetic Stimulation (TMS) may be a suitable approach for studying top-down control of visceromotor processes. However, there is inconsistent evidence as to whether TMS can modify cardiovascular autonomic states. One reason for the inconsistency may arise from the lack of studies accounting for the acute affective states of participants with respect to the stimulation procedures. To gain more insights into these processes, we evaluated the effects of intermittent and continuous theta-burst stimulation (TBS) to the right frontotemporal cortex on state anxiety and cardiovascular responses in a preliminary study. State anxiety significantly increased for both intermittent and continuous TBS relative to sham. Intermittent TBS also significantly increased heart-rate variability (HRV) at natural and slow-paced breathing rates. The effect of intermittent TBS on vagally-mediated HRV was attenuated after accounting for stimulation-induced anxiety, suggesting that increased HRV after stimulation may reflect a response to a transient stressor (i.e., the stimulation itself), rather than TBS effects on visceromotor networks. In contrast, continuous TBS increased pulse transit time latency across breathing rates, an effect that was enhanced after accounting for state anxiety. TMS is a promising approach to study cortical involvement in cardiovascular autonomic regulation. The findings show that TBS induces effects on visceromotor networks, and that analysis of state covariates such as anxiety can be important for increasing the precision of these estimates. Future non-invasive brain stimulation studies of top-down neurocardiac regulation should account for the potential influence of non-specific arousal or anxiety responses to stimulation.
  • References (63)
  • Citations (0)
馃摉 Papers frequently viewed together
25 Citations
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Huan Song (KI: Karolinska Institutet)H-Index: 13
#2Fang Fang (KI: Karolinska Institutet)H-Index: 28
Last. Unnur Valdimarsd贸ttir (KI: Karolinska Institutet)H-Index: 31
view all 10 authors...
Abstract Objective To assess the association between stress related disorders and subsequent risk of cardiovascular disease. Design Population based, sibling controlled cohort study. Setting Population of Sweden. Participants 136鈥637 patients in the Swedish National Patient Register with stress related disorders, including post-traumatic stress disorder (PTSD), acute stress reaction, adjustment disorder, and other stress reactions, from 1987 to 2013; 171鈥314 unaffected full siblings of these pat...
4 CitationsSource
#1Hyeong-Dong Park (EPFL: 脡cole Polytechnique F茅d茅rale de Lausanne)H-Index: 7
#2Fosco Bernasconi (EPFL: 脡cole Polytechnique F茅d茅rale de Lausanne)H-Index: 6
Last. Olaf Blanke (EPFL: 脡cole Polytechnique F茅d茅rale de Lausanne)H-Index: 53
view all 8 authors...
Recent research has shown that heartbeat-evoked potentials (HEPs), brain activity in response to heartbeats, are a useful neural measure for investigating the functional role of brain-body interactions in cognitive processes including self-consciousness. In 2 experiments, using intracranial electroencephalography (EEG), we investigated (1) the neural sources of HEPs, (2) the underlying mechanisms for HEP generation, and (3) the functional role of HEPs in bodily self-consciousness. In Experiment-...
28 CitationsSource
#1Vincenzo De Cicco (UniPi: University of Pisa)H-Index: 3
#2Maria Paola Tramonti Fantozzi (UniPi: University of Pisa)H-Index: 3
Last. Diego Manzoni (UniPi: University of Pisa)H-Index: 21
view all 7 authors...
It is known that sensory signals sustain the background discharge of the Ascending Reticular Activating System (ARAS) which includes the noradrenergic LC neurons and controls the level of attention and alertness. Moreover, LC neurons influence brain metabolic activity, gene expression and brain inflammatory processes. As a consequence of the sensory control of ARAS/LC, stimulation of a sensory channel may potential influence neuronal activity and trophic state all over the brain, supporting cogn...
4 CitationsSource
#1Annie T. Ginty (Baylor University)H-Index: 18
#2Thomas E. Kraynak (University of Pittsburgh)H-Index: 6
Last. Peter J. Gianaros (University of Pittsburgh)H-Index: 43
view all 4 authors...
Abstract Psychologically stressful experiences evoke changes in cardiovascular physiology that may influence risk for cardiovascular disease (CVD). But what are the neural circuits and intermediate physiological pathways that link stressful experiences to cardiovascular changes that might in turn confer disease risk? This question is important because it has broader implications for our understanding of the neurophysiological pathways that link stressful and other psychological experiences to ph...
16 CitationsSource
#1Chris Baecken (UGent: Ghent University)H-Index: 30
#2Romain Duprat (UGent: Ghent University)H-Index: 8
Last. Kees van Heeringen (UGent: Ghent University)H-Index: 31
view all 5 authors...
Abstract Background Accelerated repetitive transcranial magnetic stimulation paradigms have been shown to result in fast decreases in depressive symptoms and suicidal ideation. Although the subgenual anterior cingulate cortex (sgACC) region has been put forward as a possible biological marker, so far, no studies evaluated the clinical effects of accelerated intermittent theta burst stimulation (aiTBS) on sgACC functional connectivity (FC). Methods Fifty patients with treatment-resistant depressi...
17 CitationsSource
#1Chris Baecken (Vrije Universiteit Brussel)H-Index: 30
#2Jean-Pascal Lefaucheur (University of Paris)H-Index: 42
Last. Peter Van Schuerbeek (Vrije Universiteit Brussel)H-Index: 14
view all 3 authors...
Abstract Objective Although accelerated repetitive transcranial magnetic stimulation (rTMS) designs seem to be able to alleviate mood over a relatively short period of time, no studies yet examined the cellular effects on neurochemicals with regard to working mechanisms, safety and neural integrity. Methods Eighteen right-handed antidepressant-free unipolar treatment resistant depressed (TRD) patients participated in this sham-controlled accelerated high frequency (aHF)-rTMS 1 H MR spectroscopy ...
13 CitationsSource
#1Michel-Pierre Coll ('KCL': King's College London)H-Index: 8
#2Tegan PentonH-Index: 3
Last. Hannah HobsonH-Index: 5
view all 3 authors...
Comment on: Changes in interoceptive processes following brain stimulation by Pollatos, Herbert, Mai & Kammer, 2016
5 CitationsSource
#1Elena MakovacH-Index: 10
#2Julian F. Thayer (OSU: Ohio State University)H-Index: 74
Last. Cristina OttavianiH-Index: 19
view all 3 authors...
Abstract Given the intrinsic connection between the brain and the heart, a recent body of research emerged with the aim to influence cardiovascular system functioning by non-invasive brain stimulation (NIBS) methods such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Despite the implications of cardiovascular activity modulation for therapeutic purposes, such effects of NIBS have not yet been quantified. The aim of this study was to meta-analyze stud...
18 CitationsSource
#1Sarina J. Iwabuchi (University of Nottingham)H-Index: 10
#2Felix RaschkeH-Index: 7
Last. Lena Palaniyappan (Lawson Health Research Institute)H-Index: 27
view all 6 authors...
Abstract Repetitive transcranial magnetic stimulation (rTMS) has been used worldwide to treat depression. However, the exact physiological effects are not well understood. Pathophysiology of depression involves crucial limbic structures (e.g. insula), and it is still not clear if these structures can be modulated through neurostimulation of surface regions (e.g. dorsolateral prefrontal cortex, DLPFC), and whether rTMS-induced excitatory/inhibitory transmission alterations relate to fronto-limbic...
20 CitationsSource
#1Christoph Berger (University of Rostock)H-Index: 39
#2Gregor Domes (University of Freiburg)H-Index: 36
Last. J. H枚ppnerH-Index: 12
view all 5 authors...
Repetitive transcranial magnetic stimulation (rTMS) can modulate the excitability of stimulated cortical areas, such as prefrontal areas involved in emotion regulation. Low frequency (LF) rTMS is expected to have inhibitory effects on prefrontal regions, and thereby should disinhibit limbic activity, resulting in enhanced emotional and autonomic reactions. For high frequency (HF) rTMS, the opposite pattern might be assumed. The objective of this study was to determine the effects of different rT...
4 CitationsSource
Cited By0