AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis
Abstract
Although it has been known that protein synthesis is suppressed in sepsis, which cannot be corrected by leucine supplement (also known as leucine resistance), the molecular signaling mechanism remains unclear. This study aimed to investigate the AMP‐activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) pathway in sepsis‐induced leucine resistance and its upstream signals, and to seek a way to correct leucine resistance in sepsis....
Paper Details
Title
AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis
Published Date
Jan 22, 2020
Journal
Volume
44
Issue
5
Pages
1133 - 1141
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